[HTML][HTML] Impact of oxidative stress on age-associated decline in oocyte developmental competence

H Sasaki, T Hamatani, S Kamijo, M Iwai… - Frontiers in …, 2019 - frontiersin.org
… reduces ATP synthesis and influences the meiotic spindle … , its lack of protective histones,
and deficiency of efficient repair … ) in oocytes from Drp1-deficient mice, resulting in impaired Ca …

Melatonin protects against chronic stress-induced oxidative meiotic defects in mice MII oocytes by regulating SIRT1

Y Guo, J Sun, S Bu, B Li, Q Zhang, Q Wang, D Lai - Cell Cycle, 2020 - Taylor & Francis
… In addition, the deficit of mitochondria-derived ATP during oxidative stress impairs mouse
oocyte spindles [Citation35]. SIRT1 is also a regulator of ROS homeostasis [Citation13] and the …

Toxicant effects on mammalian oocyte mitochondria

KF Malott, U Luderer - Biology of Reproduction, 2021 - academic.oup.com
spindle assembly and chromosome alignment, two ATP-… MXC and rotenone induce ovarian
oxidative damage [91, 94], … and that glyphosate hinders the ability of the oocyte to effectively …

Triclocarban exposure affects mouse oocyte in vitro maturation through inducing mitochondrial dysfunction and oxidative stress

ZM Ding, MJ Ahmad, F Meng, F Chen, YS Wang… - Environmental …, 2020 - Elsevier
oocytes experienced MII stage, while most of TCC-treated … TCC treated oocytes, suggesting
any disruption at spindle structure and/… reducing ATP content, which further disrupted oocyte

Mitochondrial activity and redox status in oocytes from old mice: The interplay between maternal and postovulatory aging

K Czajkowska, A Ajduk - Theriogenology, 2023 - Elsevier
… Two phenotypes of MII oocytes isolated from mice in … that the genetic background of mice
affects oocytes and embryos’ … oocyte aneuploidy and meiotic spindle defects in mice by dietary …

Oocyte mitochondria—Key regulators of oocyte function and potential therapeutic targets for improving fertility

D Adhikari, I Lee, WS Yuen, J Carroll - Biology of Reproduction, 2022 - academic.oup.com
… with energy deficiency and oxidative stress. Pharmacological … More recently, the role of
mitochondria-derived metabolites in … -15) during in vitro maturation protects against spindle and …

[HTML][HTML] Oxidative stress induces meiotic defects of oocytes in a mouse psoriasis model

ZQ Zhang, SB Tang, YY Jiang, FY Long, F He… - Cell Death & …, 2022 - nature.com
… We discover that oocytes from psoriasis-like mice display spindle/… -like mice show peroxidation
and this peroxidation affects the … Ψm was the driving force for the synthesis of ATP. Red …

Mitochondria-targeted therapeutics, MitoQ and BGP-15, reverse aging-associated meiotic spindle defects in mouse and human oocytes

U Al-Zubaidi, D Adhikari, O Cinar, QH Zhang… - Human …, 2021 - academic.oup.com
… Mitochondrial dysfunction that causes a decrease in ATP and/or an increase in ROS is …
of MitoQ and BGP-15 in our oxidative stress model, in-vitro matured MII oocytes from young …

[HTML][HTML] Melatonin protects against Mdivi-1-induced abnormal spindle assembly and mitochondrial superoxide production during porcine oocyte maturation

SG Yang, SY Joe, JW Bae, GD Heo, HJ Park… - Frontiers in cell and …, 2021 - frontiersin.org
… -1 promotes the deficiency of spindle assembly by disturbing … suppresses oxidative
stress and restores abnormal spindlespindle assembly dynamics, and mitochondria-derived

[HTML][HTML] The role of mitochondria in oocyte maturation

A Kirillova, JEJ Smitz, GT Sukhikh, I Mazunin - Cells, 2021 - mdpi.com
… microtubules are assembled from the opposite spindle poles … most likely is not severely
impaired due to in vitro conditions. … Oxidative stress can severely harm the oocyte’s function by …